Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.6.1.43 extracted from

  • James, A.W.; Gowsalya, R.; Nachiappan, V.
    Dolichyl pyrophosphate phosphatase-mediated N-glycosylation defect dysregulates lipid homeostasis in Saccharomyces cerevisiae (2016), Biochim. Biophys. Acta, 1861, 1705-1718 .
    View publication on PubMed
Search for more literature for 3.6.1.43

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dolichyl diphosphate + H2O Saccharomyces cerevisiae
-
 dolichyl phosphate + phosphate
-
 ?
dolichyl diphosphate + H2O Saccharomyces cerevisiae BY4741
-
 dolichyl phosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-
Saccharomyces cerevisiae BY4741
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dolichyl diphosphate + H2O
-
 Saccharomyces cerevisiae dolichyl phosphate + phosphate
-
 ?
dolichyl diphosphate + H2O
-
 Saccharomyces cerevisiae BY4741 dolichyl phosphate + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
CAX4
-
 Saccharomyces cerevisiae
Dol-PP phosphatase
-
 Saccharomyces cerevisiae
dolichyl pyrophosphate phosphatase
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
malfunction in enzyme-deficient cells showing endoplasmic reticulum stress, membrane and growth defect, the N-glycosylation of the vacuolar carboxypeptidase is severely affected, and expression of the endoplasmic reticulum chaperone Kar2p is elevated, which results in unfolded protein response activation as an adaptive response Saccharomyces cerevisiae
metabolism the enzyme is essential for phospholipid homeostasis Saccharomyces cerevisiae
physiological function the enzyme regulates membrane biogenesis by coordinating lipid homeostasis with protein quality control Saccharomyces cerevisiae